The Cubs will open and close the 2012 season at Wrigley next season. The opener will be Aprl 5th vs. the Washington Nationals and I presume Stephen Strasburg. They'll close against the Houston Astros on October 3rd. Interleague series include the annual home and home versus the White Sox (@ Wrigley from May 18-20 and @ The Cell from June 18-20).
Cubs 2012 Schedule