UPDATED 9/27: 

The Cubs have selected the contract of LHP Brailyn Marquez, and to make room for him on the MLB Reserve List (40-man roster) 1B-3B Patrick Wisdom has been Designated for Assignment (DFA). 

Because he was outrighted to the minors previously in his career, Wisdom is an Article XX-D player and has the right to elect free-agency if he is outrighted to the minors. 

Marquez was eligible for selection in the 2020 Rule 5 Draft, so as the Cubs #1 pitching prospect he was a virtual lock to be added to the ML:B 40-man roster by the 11/20 deadline anyway. And because he was called up to MLB the last day of the MLB regular season, Marquez will accrue one day of MLB Service Time (which is pro-rated as three days of MLB Service Time in 2020). He also will have Draft-Excluded Status this coming off-season, meaning if he is not sent outright to the minors prior to the Rule 5 Draft he cannot be sent to the minors (optioned or outrighted) or Designated for Assignment any earlier than 20 days prior to MLB Opening Day. He can be traded, non-tendered on 12/2, or released, however.  

While Marquez does not automatically qualify for he Cubs Post-Season Roster Eligibility List, he was in the Cubs organization and was assigned to the Cubs MLB Club Player Pool as of midnight 9/15, so he could replace any of the players who are on the Cubs MLB 45-day IL (Descalso, Norwood, Rodriguez, or Wieck) on the Post-Season Roster Eligibility List (TBD).

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LAST UPDATED  9-27-2020

As things stand right now...

9/27 UPDATE: 

The Cubs have selected the contract of LHP Brailyn Marquez, and to make room for Marquez on the MLB Reserve List (40-man roster) and the MLB 28-man Active List roster, 1B-3B Patrick Wisdom has been Designated for Assignment.  

So the Cubs MLB Club Player Pool now stands at 58 (two slots are open).

The Cubs close out the 2020 regular season sleeping in their own beds but hosted by their South Side rivals, the White Sox. The Cubs enter the series 2.5 games up. The Cardinals have 6 games remaining to the Cubs' 3. The Cubs' magic number stands at 3 games as of my writing this. See below for the daily match-ups.

The Cubs lost a tight game (and solid performance from Hendricks) last night, but they remain 3.5 ahead of the Cardinals. There are only 4 games left for the offense to build any confidence going into the postseason. They'll have a chance to even the series this afternoon in Pittsburgh.

The Cubs clinched a playoff spot despite the loss last night. Clinching the division and sorting out their offense remain on the to-do list, and they've got five games left in which to scratch off those tasks. Two games remain in Pittsburgh and the series stands 1-1.

With last night's shutout victory, the Cubs (32-22) are now 4.5 games ahead of the virtually tied Cardinals and Reds. They'll call up Jose Quintana for his first start (and third appearance) of 2020. Meanwhile, Bryant is out with an oblique injury and Rex Brothers is sent down to make room for Quintana. 6 total games remain and the Cubs' magic number stands at 4 (because the Cards have 9 games left).